Rex Ryan always made it a point to make it kind of personal when he went against the New England Patriots as the head coach of the New York Jets. No one expects much to change now that he is at the helm of another AFC East rival, the Buffalo Bills. It is with this in mind that NFL bettors will check out these two teams in action, starting at 1 PM ET at Ralph Wilson Stadium in Orchard Park, NY.

The Bills were the NFL’s best defense last season with regard to points allowed per drive, and they retained much of their strength from last season, with the only major differences being the absence of linebacker Kiko Alonso (trade), who was injured anyway, and the switch from Jim Schwartz to Dennis Thurman as the defensive coordinator. They were a real pain in the neck for Andrew Luck to deal with last week. Luck completed just 26 of his 49 passes and tossed two interceptions, as the Bills were in his face much of the day. By getting out to a two-touchdown lead early, the Bills also rendered Indy’s revamped running game relatively useless. And Tyrod Taylor, the starting quarterback as named by Ryan, went 14 of 19 for 195 yards, and did not suffer a sack.

What was kind of interesting about Buffalo’s performance last Sunday was that LeSean McCoy was not a very big part of it. McCoy had 17 carries for 41 yards, a paltry 2.4 yards per attempt. However, Karlos Williams was available for some balance (six carries, 55 yards) and that will be some comfort for Buffalo fans, since McCoy  is reportedly still bothered by a bad hamstring. Those injuries have a way of lingering.

In the NFL betting odds that are posted on this game, the Bills are very slight favorites: