For the first time in 14 years only two No. 1 seeds have reached the NCAA Tournament’s Sweet 16. As upset-filled as this Big Dance has been, would it surprise anyone if both were eliminated on Friday night even as solid betting favorites?

Odds courtesy of OddsShark.com

The only region that has come close to going to form has been the East, where No. 1 Villanova faces No. 5 West Virginia in the first game Friday from Boston, and No. 2 Purdue and No. 3 Texas Tech square off in the nightcap. The No. 4 seed in the region, Wichita State, was upset in the first round as a double-digit favorite against No. 13 Marshall.

West Virginia then dismantled Marshall in Round 2 to at least claim the state championship. WVU is a 5-point underdog against Villanova. It should be a fascinating matchup because the Mountaineers bring more full-court defensive pressure than any team in the nation. The Wildcats, meanwhile, were the country’s highest-scoring team this season. The two were former Big East foes, playing 42 times overall previously and last in December 2011.