For only the third time in the Eli Manning era, the New York Giants are favored on the road against the Philadelphia Eagles. Odds courtesy of OddsShark.com

The Giants are listed as three-point favorites against the Eagles with a 41.5-point total in the Thursday Night Football matchup. The Giants are 6-1-1 ATS in their last eight games as a favorite of three points or fewer, but the Eagles are also in a rut in divisional games – 0-4 SU and ATS in their last four games against NFC East teams.

The Giants, who are 10-4 SU and 7-5-2 ATS, will face some challenges when they have the ball on Thursday. New York’s offensive line often struggles to open running lanes, and while they have allowed just 21 sacks much of that stems from Manning’s quick release. The Eagles also have some marauding defenders such as DT Fletcher Cox, DE Brandon Graham and DE Vince Curry who can bring pressure from many angles.

Wide receiver Odell Beckham Jr. has averaged 74.8 yards in five career games against Philadelphia. If Manning’s protection is strong, the Giants should be able to take advantage of the Eagles’ pass coverage. Philadelphia lacks depth at cornerback and allows 7.7 yards per pass, seventh-worst in the league.